The Synthetic α-Bromo-2′,3,4,4′-Tetramethoxychalcone (α-Br-TMC) Inhibits the JAK/STAT Signaling Pathway

Signal transducer and activator of transcription STAT5 and its upstream activating kinase JAK2 are essential mediators of cytokine signaling. Their activity is normally tightly regulated and transient. However, constitutive activation of STAT5 is found in numerous cancers and a driving force for mal...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pinz, Sophia, Unser, Samy, Brueggemann, Susanne, Besl, Elisabeth, Al-Rifai, Nafisah, Petkes, Hermina, Amslinger, Sabine, Rascle, Anne
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2014
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940872/
https://ncbi.nlm.nih.gov/pubmed/24595334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090275
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