Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice

AIMS/HYPOTHESIS: Obesity is associated with ageing and increased energy intake, while restriction of energy intake improves health and longevity in multiple organisms; the NAD(+)-dependent deacetylase sirtuin 1 (SIRT1) is implicated in this process. Pro-opiomelanocortin (POMC) and agouti-related pep...

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Main Authors: Sasaki, Tsutomu, Kikuchi, Osamu, Shimpuku, Mayumi, Susanti, Vina Yanti, Yokota-Hashimoto, Hiromi, Taguchi, Ryo, Shibusawa, Nobuyuki, Sato, Takashi, Tang, Lijun, Amano, Kosuke, Kitazumi, Tomoya, Kuroko, Mitsutaka, Fujita, Yuki, Maruyama, Jun, Lee, Yong-soo, Kobayashi, Masaki, Nakagawa, Takashi, Minokoshi, Yasuhiko, Harada, Akihiro, Yamada, Masanobu, Kitamura, Tadahiro
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940852/
https://ncbi.nlm.nih.gov/pubmed/24374551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-013-3140-5
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