FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization

Genetic studies revealed that the ablation of insulin/IGF-1 signaling in the pancreas causes diabetes. FoxO1 is a downstream transcription factor of insulin/IGF-1 signaling. We previously reported that FoxO1 haploinsufficiency restored β cell mass and rescued diabetes in IRS2 knockout mice. However,...

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Main Authors: Kikuchi, Osamu, Kobayashi, Masaki, Amano, Kosuke, Sasaki, Tsutomu, Kitazumi, Tomoya, Kim, Hye-Jin, Lee, Yong-Soo, Yokota-Hashimoto, Hiromi, Kitamura, Yukari-Ido, Kitamura, Tadahiro
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285669/
https://ncbi.nlm.nih.gov/pubmed/22384192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032249
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