Effect of Arginase Inhibition on Pulmonary L-Arginine Metabolism in Murine Pseudomonas Pneumonia

RATIONALE: Infection of the lung with Pseudomonas aeruginosa results in upregulation of nitric oxide synthases (NOS) and arginase expression, and both enzymes compete for L-arginine as substrate. Nitric oxide (NO) production may be regulated by arginase as it controls L-arginine availability for NOS...

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Main Authors: Mehl, Anne, Ghorbani, Peyman, Douda, David, Huang, Hailu, Palaniyar, Nades, Ratjen, Felix, Grasemann, Hartmut
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940779/
https://ncbi.nlm.nih.gov/pubmed/24595185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090232
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