Multitracer Stable Isotope Quantification of Arginase and Nitric Oxide Synthase Activity in a Mouse Model of Pseudomonas Lung Infection

Cystic fibrosis airways are deficient for L-arginine, a substrate for nitric oxide synthases (NOSs) and arginases. The rationale for this study was to quantify NOS and arginase activity in the mouse lung. Anesthetized unventilated mice received a primed constant stable isotope intravenous infusion c...

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Detalhes bibliográficos
Main Authors: Grasemann, Hartmut, Jaecklin, Thomas, Mehl, Anne, Huang, Hailu, Rafii, Mahroukh, Pencharz, Paul, Ratjen, Felix
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142665/
https://ncbi.nlm.nih.gov/pubmed/25177109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/323526
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