NG2, a novel proapoptotic receptor, opposes integrin α4 to mediate anoikis through PKCα-dependent suppression of FAK phosphorylation

Disruption of cell–matrix interactions can lead to anoikis – apoptosis due to loss of matrix contacts. Altered fibronectin (FN) induces anoikis of primary human fibroblasts by a novel signaling pathway characterized by reduced phosphorylation of focal adhesion kinase (FAK). However, the receptors in...

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Autores principales: Joo, NE, Watanabe, T, Chen, C, Chekenya, M, Stallcup, WB, Kapila, YL
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940336/
https://ncbi.nlm.nih.gov/pubmed/18292781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2008.22
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