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Differential phosphorylation of NG2 proteoglycan by ERK and PKCα helps balance cell proliferation and migration

Two distinct Thr phosphorylation events within the cytoplasmic domain of the NG2 proteoglycan help regulate the cellular balance between proliferation and motility. Protein kinase Cα mediates the phosphorylation of NG2 at Thr(2256), resulting in enhanced cell motility. Extracellular signal–regulated...

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Bibliografiske detaljer
Main Authors: Makagiansar, Irwan T., Williams, Scott, Mustelin, Tomas, Stallcup, William B.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064431/
https://ncbi.nlm.nih.gov/pubmed/17591920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200612084
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