Identification of an Inhibitory Mechanism of Luteolin on Insulin-like Growth Factor-1 Ligand-receptor Interaction

Using single-molecule force measurement and single-molecule fluorescence imaging, we demonstrated that luteolin is able to perform an inhibitory effect on IGF-1 ligand-receptor binding, the initial step of IGF-1 signaling. Furthermore, this inhibition mechanism was also confirmed by flow cytometry a...

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Détails bibliographiques
Auteurs principaux: Yang, Yong, Shen, Jianliang, Yu, Xujiang, Qin, Guoting, Zhang, Mingzhen, Shen, Haifa, Mao, Zongwan, Ferrari, Mauro
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940256/
https://ncbi.nlm.nih.gov/pubmed/23630137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201300082
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