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Structural basis of conformational transitions in the active site and 80′s loop in the FK506-binding protein FKBP12
The extensive set of NMR doublings exhibited by the immunophilin FKBP12 (FK506-binding protein 12) arose from a slow transition to the cis-peptide configuration at Gly(89) near the tip of the 80′s loop, the site for numerous protein-recognition interactions for both FKBP12 and other FKBP domain prot...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Portland Press Ltd.
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3940039/ https://ncbi.nlm.nih.gov/pubmed/24405377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131429 |
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