Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling

BACKGROUND: Nuclear factor erythroid-2-related factor-2 (Nrf2) is known to protect against tissue injury by orchestrating antioxidant and detoxification responses to oxidative stress. This study investigated whether upregulation of Nrf2-dependent signaling by oleanolic acid (OA), which is known to a...

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Autores principales: Hong, Yu Ah, Lim, Ji Hee, Kim, Min Young, Kim, Eun Nim, Koh, Eun Sil, Shin, Seok Joon, Choi, Bum Soon, Park, Cheol Whee, Chang, Yoon Sik, Chung, Sungjin
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939938/
https://ncbi.nlm.nih.gov/pubmed/24559268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-12-50
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