Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2–V3 interaction and modulates neutralization sensitivity

Elicitation of broadly neutralizing antibodies is essential for the development of a protective vaccine against HIV-1. However, the native HIV-1 envelope adopts a protected conformation that conceals highly conserved sites of vulnerability from antibody recognition. Although high-definition structur...

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Detalhes bibliográficos
Main Authors: Cimbro, Raffaello, Gallant, Thomas R., Dolan, Michael A., Guzzo, Christina, Zhang, Peng, Lin, Yin, Miao, Huiyi, Van Ryk, Donald, Arthos, James, Gorshkova, Inna, Brown, Patrick H., Hurt, Darrell E., Lusso, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939864/
https://ncbi.nlm.nih.gov/pubmed/24569807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314718111
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