Global Analysis of mRNA Isoform Half-Lives Reveals Stabilizing and Destabilizing Elements in Yeast

We measured half-lives of 21,248 mRNA 3′ isoforms in yeast by rapidly depleting RNA polymerase II from the nucleus and performing direct RNA sequencing throughout the decay process. Interestingly, half-lives of mRNA isoforms from the same gene, including nearly identical isoforms, often vary widely....

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Bibliografiske detaljer
Main Authors: Geisberg, Joseph V., Moqtaderi, Zarmik, Fan, Xiaochun, Ozsolak, Fatih, Struhl, Kevin
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939777/
https://ncbi.nlm.nih.gov/pubmed/24529382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.12.026
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