Axonal transport of TDP-43 mRNA granules in neurons is impaired by ALS-causing mutations

The RNA binding protein TDP-43 regulates RNA metabolism at multiple levels, including transcription, RNA splicing, and mRNA stability. TDP-43 is a major component of the cytoplasmic inclusions characteristic of amyotrophic lateral sclerosis and some types of frontotemporal lobar degeneration. The im...

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Detalhes bibliográficos
Main Authors: Alami, Nael H., Smith, Rebecca B., Carrasco, Monica A., Williams, Luis A., Winborn, Christina S., Han, Steve S. W., Kiskinis, Evangelos, Winborn, Brett, Freibaum, Brian D., Kanagaraj, Anderson, Clare, Alison J., Badders, Nisha M., Bilican, Bilada, Chaum, Edward, Chandran, Siddharthan, Shaw, Christopher E., Eggan, Kevin C., Maniatis, Tom, Taylor, J. Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939050/
https://ncbi.nlm.nih.gov/pubmed/24507191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.12.018
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