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The membrane proximal region of the cannabinoid receptor CB(1) N-terminus can allosterically modulate ligand affinity
The human cannabinoid receptor, CB(1), a G protein-coupled receptor (GPCR), contains a relatively long (∼110 a.a.) amino terminus, whose function is still not defined. Here we explore a potential role for the CB(1) N-terminus in modulating ligand binding to the receptor. We find that although most o...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3938390/ https://ncbi.nlm.nih.gov/pubmed/24206272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400842k |
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