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Synthesis of QS-21-Based Immunoadjuvants

Three structurally defined QS-21-based immune adjuvant candidates (2a-2c) have been synthesized. Application of the two-stage activation glycosylation approach utilizing allyl glycoside building blocks improved the synthetic accessibility of the new adjuvants. The efficient synthesis and establishme...

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Autori principali: Wang, Pengfei, Dai, Qipu, Thogaripally, Punith, Zhang, Ping, Michalek, Suzanne M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937867/
https://ncbi.nlm.nih.gov/pubmed/24147602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo402118j
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