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Synthesis and Evaluation of QS-7-Based Vaccine Adjuvants

We have designed and synthesized two analogs (5 and 6) of QS-7, a natural saponin compound isolated from Quillaja saponaria (QS) Molina tree bark. The only structural difference between compound 5 and 6 is that 5 is acetylated at the 3- and 4-O positions of the quillaic acid C28 fucosyl unit while 6...

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Detalles Bibliográficos
Publicado en:ACS Infect Dis
Main Authors: Wang, Pengfei, Škalamera, Đani, Sui, Xianwei, Zhang, Ping, Michalek, Suzanne M.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6848976/
https://ncbi.nlm.nih.gov/pubmed/30920199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00039
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