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Synthesis and Evaluation of QS-21-Based Immunoadjuvants with a Terminal-Functionalized Side Chain Incorporated in the West Wing Trisaccharide

Three QS-21-based vaccine adjuvant candidates with a terminal-functionalized side chain incorporated in the west wing trisaccharide have been synthesized. The terminal polar functional group serves to increase the solubility of these analogues in water. Two of the synthetic analogues have been shown...

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Publicado en:J Org Chem
Main Authors: Wang, Pengfei, Devalankar, Dattatray A., Dai, Qipu, Zhang, Ping, Michalek, Suzanne M
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6488304/
https://ncbi.nlm.nih.gov/pubmed/27709937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.6b00922
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