High-throughput de novo screening of receptor agonists with an automated single-cell analysis and isolation system

Reconstitution of signaling pathways involving single mammalian transmembrane receptors has not been accomplished in yeast cells. In this study, intact EGF receptor (EGFR) and a cell wall-anchored form of EGF were co-expressed on the yeast cell surface, which led to autophosphorylation of the EGFR i...

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Detalhes bibliográficos
Main Authors: Yoshimoto, Nobuo, Tatematsu, Kenji, Iijima, Masumi, Niimi, Tomoaki, Maturana, Andrés D., Fujii, Ikuo, Kondo, Akihiko, Tanizawa, Katsuyuki, Kuroda, Shun'ichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937795/
https://ncbi.nlm.nih.gov/pubmed/24577528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04242
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