Oligomerization-induced Conformational Change in the C-terminal Region of Nel-like Molecule 1 (NELL1) Protein Is Necessary for the Efficient Mediation of Murine MC3T3-E1 Cell Adhesion and Spreading

NELL1 is a large oligomeric secretory glycoprotein that functions as an osteoinductive factor. NELL1 contains several conserved domains, has structural similarities to thrombospondin 1, and supports osteoblastic cell adhesion through integrins. To define the structural requirements for NELL1-mediate...

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Main Authors: Nakamura, Yoko, Hasebe, Ai, Takahashi, Kaneyoshi, Iijima, Masumi, Yoshimoto, Nobuo, Maturana, Andrés D., Ting, Kang, Kuroda, Shun'ichi, Niimi, Tomoaki
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Glycobiology and Extracellular Matrices
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3975024/
https://ncbi.nlm.nih.gov/pubmed/24563467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.507020
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