Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival

ATP8A2 is a P(4)-ATPase that is highly expressed in the retina, brain, spinal cord and testes. In the retina, ATP8A2 is localized in photoreceptors where it uses ATP to transport phosphatidylserine (PS) and phosphatidylethanolamine (PE) from the exoplasmic to the cytoplasmic leaflet of membranes. Al...

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Detalhes bibliográficos
Main Authors: Coleman, Jonathan A., Zhu, Xianjun, Djajadi, Hidayat R., Molday, Laurie L., Smith, Richard S., Libby, Richard T., John, Simon W. M., Molday, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937779/
https://ncbi.nlm.nih.gov/pubmed/24413176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.145052
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