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C-terminus of the P4-ATPase ATP8A2 functions in protein folding and regulation of phospholipid flippase activity
ATP8A2 is a P4-ATPase that flips phosphatidylserine and phosphatidylethanolamine across cell membranes. This generates membrane phospholipid asymmetry, a property important in many cellular processes, including vesicle trafficking. ATP8A2 deficiency causes severe neurodegenerative diseases. We inves...
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| Publié dans: | Mol Biol Cell |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Cell Biology
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341728/ https://ncbi.nlm.nih.gov/pubmed/27932490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-06-0453 |
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