The Mon1–Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold–Rab interface and association with PI3P-positive membranes

To function in fusion and signaling, Rab GTPases need to be converted into their active GTP form. We previously identified the conserved Mon1–Ccz1 complex as the guanine nucleotide exchange factor (GEF) of the yeast Rab7 GTPase Ypt7. To address the possible GEF mechanism, we generated a homology mod...

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Autores principales: Cabrera, Margarita, Nordmann, Mirjana, Perz, Angela, Schmedt, David, Gerondopoulos, Andreas, Barr, Francis, Piehler, Jacob, Engelbrecht-Vandré, Siegfried, Ungermann, Christian
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937774/
https://ncbi.nlm.nih.gov/pubmed/24413168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.140921
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