Benzothiazinones Mediate Killing of Corynebacterineae by Blocking Decaprenyl Phosphate Recycling Involved in Cell Wall Biosynthesis

Benzothiazinones (BTZs) are a new class of sulfur containing heterocyclic compounds that target DprE1, an oxidoreductase involved in the epimerization of decaprenyl-phosphoribose (DPR) to decaprenyl-phosphoarabinose (DPA) in the Corynebacterineae, such as Corynebacterium glutamicum and Mycobacterium...

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Bibliographic Details
Main Authors: Grover, Shipra, Alderwick, Luke J., Mishra, Arun K., Krumbach, Karin, Marienhagen, Jan, Eggeling, Lothar, Bhatt, Apoorva, Besra, Gurdyal S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937683/
https://ncbi.nlm.nih.gov/pubmed/24446451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.522623
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