Phosphatidylinositol 4,5-Biphosphate (PIP(2)) Modulates Interaction of Syntaxin-1A with Sulfonylurea Receptor 1 to Regulate Pancreatic β-Cell ATP-sensitive Potassium Channels

In β-cells, syntaxin (Syn)-1A interacts with SUR1 to inhibit ATP-sensitive potassium channels (K(ATP) channels). PIP(2) binds the Kir6.2 subunit to open K(ATP) channels. PIP(2) also modifies Syn-1A clustering in plasma membrane (PM) that may alter Syn-1A actions on PM proteins like SUR1. Here, we as...

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Detalhes bibliográficos
Main Authors: Liang, Tao, Xie, Li, Chao, Christin, Kang, Youhou, Lin, Xianguang, Qin, Tairan, Xie, Huanli, Feng, Zhong-Ping, Gaisano, Herbert Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937670/
https://ncbi.nlm.nih.gov/pubmed/24429282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.511808
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