Syntaxin-1A Interacts with Distinct Domains within Nucleotide-binding Folds of Sulfonylurea Receptor 1 to Inhibit β-Cell ATP-sensitive Potassium Channels

The ATP-sensitive potassium (K(ATP)) channel regulates pancreatic β-cell function by linking metabolic status to electrical activity. Syntaxin-1A (Syn-1A), a SNARE protein mediating exocytotic fusion, binds and inhibits the K(ATP) channel via the nucleotide-binding folds (NBFs) of its sulfonylurea r...

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Detalhes bibliográficos
Main Authors: Chang, Nathan, Liang, Tao, Lin, Xianguang, Kang, Youhou, Xie, Huanli, Feng, Zhong-Ping, Gaisano, Herbert Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123096/
https://ncbi.nlm.nih.gov/pubmed/21540180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.217950
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