Differential Regulation of the Ten-Eleven Translocation (TET) Family of Dioxygenases by O-Linked β-N-Acetylglucosamine Transferase (OGT)

The ten-eleven translocation (TET) family of dioxygenases (TET1/2/3) converts 5-methylcytosine to 5-hydroxymethylcytosine and provides a vital mechanism for DNA demethylation. However, how TET proteins are regulated is largely unknown. Here we report that the O-linked β-GlcNAc (O-GlcNAc) transferase...

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Bibliografske podrobnosti
Main Authors: Zhang, Qiao, Liu, Xiaoguang, Gao, Wenqi, Li, Pishun, Hou, Jingli, Li, Jiwen, Wong, Jiemin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
DNA and Chromosomes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937666/
https://ncbi.nlm.nih.gov/pubmed/24394411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.524140
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