Filamin A Promotes Dynamin-dependent Internalization of Hyperpolarization-activated Cyclic Nucleotide-gated Type 1 (HCN1) Channels and Restricts I(h) in Hippocampal Neurons

The actin-binding protein filamin A (FLNa) regulates neuronal migration during development, yet its roles in the mature brain remain largely obscure. Here, we probed the effects of FLNa on the regulation of ion channels that influence neuronal properties. We focused on the HCN1 channels that conduct...

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Autors principals: Noam, Yoav, Ehrengruber, Markus U., Koh, Annie, Feyen, Paul, Manders, Erik M. M., Abbott, Geoffrey W., Wadman, Wytse J., Baram, Tallie Z.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937658/
https://ncbi.nlm.nih.gov/pubmed/24403084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.522060
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