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Ligand Independence of the T618I Mutation in the Colony-stimulating Factor 3 Receptor (CSF3R) Protein Results from Loss of O-Linked Glycosylation and Increased Receptor Dimerization

Mutations in the CSF3 granulocyte colony-stimulating factor receptor CSF3R have recently been found in a large percentage of patients with chronic neutrophilic leukemia and, more rarely, in other types of leukemia. These CSF3R mutations fall into two distinct categories: membrane-proximal mutations...

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Bibliografski detalji
Glavni autori: Maxson, Julia E., Luty, Samuel B., MacManiman, Jason D., Abel, Melissa L., Druker, Brian J., Tyner, Jeffrey W.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937653/
https://ncbi.nlm.nih.gov/pubmed/24403076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.508440
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