Ligand Independence of the T618I Mutation in the Colony-stimulating Factor 3 Receptor (CSF3R) Protein Results from Loss of O-Linked Glycosylation and Increased Receptor Dimerization

Mutations in the CSF3 granulocyte colony-stimulating factor receptor CSF3R have recently been found in a large percentage of patients with chronic neutrophilic leukemia and, more rarely, in other types of leukemia. These CSF3R mutations fall into two distinct categories: membrane-proximal mutations...

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Hlavní autoři: Maxson, Julia E., Luty, Samuel B., MacManiman, Jason D., Abel, Melissa L., Druker, Brian J., Tyner, Jeffrey W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937653/
https://ncbi.nlm.nih.gov/pubmed/24403076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.508440
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