Receptor-interacting Protein 1 Increases Chemoresistance by Maintaining Inhibitor of Apoptosis Protein Levels and Reducing Reactive Oxygen Species through a microRNA-146a-mediated Catalase Pathway

Although receptor-interacting protein 1 (RIP1) is well known as a key mediator in cell survival and death signaling, whether RIP1 directly contributes to chemotherapy response in cancer has not been determined. In this report, we found that, in human lung cancer cells, knockdown of RIP1 substantiall...

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Autors principals: Wang, Qiong, Chen, Wenshu, Bai, Lang, Chen, Wenjie, Padilla, Mabel T., Lin, Amy S., Shi, Shaoqing, Wang, Xia, Lin, Yong
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937640/
https://ncbi.nlm.nih.gov/pubmed/24425875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.526152
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