Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex

Initiation of eukaryotic DNA replication requires phosphorylation of the MCM complex by Dbf4-dependent kinase (DDK), composed of Cdc7 kinase and its activator, Dbf4. We report here that budding yeast Rif1 (Rap1-interacting factor 1) controls DNA replication genome-wide and describe how Rif1 opposes...

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Hauptverfasser: Hiraga, Shin-ichiro, Alvino, Gina M., Chang, FuJung, Lian, Hui-yong, Sridhar, Akila, Kubota, Takashi, Brewer, Bonita J., Weinreich, Michael, Raghuraman, M.K., Donaldson, Anne D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937515/
https://ncbi.nlm.nih.gov/pubmed/24532715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.231258.113
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