Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5′TOP mRNA translation

The mammalian target of rapamycin (mTOR) promotes cell growth and proliferation by promoting mRNA translation and increasing the protein synthetic capacity of the cell. Although mTOR globally promotes translation by regulating the mRNA 5′ cap-binding protein eIF4E (eukaryotic initiation factor 4E),...

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Bibliografski detalji
Glavni autori: Tcherkezian, Joseph, Cargnello, Marie, Romeo, Yves, Huttlin, Edward L., Lavoie, Genevieve, Gygi, Steven P., Roux, Philippe P.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2014
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3937514/
https://ncbi.nlm.nih.gov/pubmed/24532714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.231407.113
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