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The Role of Mutation Rate Variation and Genetic Diversity in the Architecture of Human Disease
BACKGROUND: We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all gene...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3937440/ https://ncbi.nlm.nih.gov/pubmed/24587257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090166 |
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