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How Much of the Variation in the Mutation Rate Along the Human Genome Can Be Explained?

It has been claimed recently that it may be possible to predict the rate of de novo mutation of each site in the human genome with a high degree of accuracy [Michaelson et al. (2012), Cell 151: 1431−1442]. We show that this claim is unwarranted. By considering the correlation between the rate of de...

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Autori principali: Eyre-Walker, Adam, Eyre-Walker, Ying Chen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Genetics Society of America 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4169158/
https://ncbi.nlm.nih.gov/pubmed/24996580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.114.012849
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