WNK1-OSR1 kinase-mediated phospho-activation of Na(+)-K(+)-2Cl(-) cotransporter facilitates glioma migration

BACKGROUND: The bumetanide (BMT)-sensitive Na(+)-K(+)-2Cl(-) cotransporter isoform 1 (NKCC1) maintains cell volume homeostasis by increasing intracellular K(+) and Cl(-) content via regulatory volume increase (RVI). Expression levels of NKCC1 positively correlate with the histological grade and seve...

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Bibliografiske detaljer
Main Authors: Zhu, Wen, Begum, Gulnaz, Pointer, Kelli, Clark, Paul A, Yang, Sung-Sen, Lin, Shih-Hua, Kahle, Kristopher T, Kuo, John S, Sun, Dandan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936893/
https://ncbi.nlm.nih.gov/pubmed/24555568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-31
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