Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models

BACKGROUND: SET/I2PP2A is a multifunctional protein that is up-regulated in head and neck squamous cell carcinoma (HNSCC). The action of SET in HNSCC tumorigenicity is unknown. METHODS: Stable SET knockdown by shRNA (shSET) was established in three HNSCC cell lines: HN12, HN13, and Cal27. Protein ex...

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Detalhes bibliográficos
Main Authors: Sobral, Lays M, Sousa, Lucas O, Coletta, Ricardo D, Cabral, Hamilton, Greene, Lewis J, Tajara, Eloiza H, Gutkind, J Silvio, Curti, Carlos, Leopoldino, Andréia M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936887/
https://ncbi.nlm.nih.gov/pubmed/24555657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-32
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