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Knockdown of Akt Sensitizes Osteosarcoma Cells to Apoptosis Induced by Cisplatin Treatment

Akt plays an important role in the inhibition of apoptosis induced by chemotherapy and other stimuli. We therefore investigated if knockdown of Akt2 promoted drug-induced apoptosis in cultured osteosarcoma cells in vitro. SAOS-2 cells were transfected with Akt2 siRNA. The sensitivity of the transfor...

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Detalhes bibliográficos
Main Authors: Zhang, Guoyou, Li, Ming, Zhu, Xiaodong, Bai, Yushu, Yang, Changwei
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International (MDPI) 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116170/
https://ncbi.nlm.nih.gov/pubmed/21686164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms12052994
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