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Knockdown of Akt Sensitizes Osteosarcoma Cells to Apoptosis Induced by Cisplatin Treatment

Akt plays an important role in the inhibition of apoptosis induced by chemotherapy and other stimuli. We therefore investigated if knockdown of Akt2 promoted drug-induced apoptosis in cultured osteosarcoma cells in vitro. SAOS-2 cells were transfected with Akt2 siRNA. The sensitivity of the transfor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Guoyou, Li, Ming, Zhu, Xiaodong, Bai, Yushu, Yang, Changwei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Molecular Diversity Preservation International (MDPI) 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116170/
https://ncbi.nlm.nih.gov/pubmed/21686164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms12052994
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