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Genetic and Pharmacologic Models for Type 1 Diabetes
Type 1 diabetes (T1D) is characterized by a partial or total insufficiency of insulin. The premiere animal model of autoimmune T cell-mediated T1D is the NOD mouse. A dominant negative mutation in the mouse insulin 2 gene (Ins2(Akita)) produces a severe insulin deficiency syndrome without autoimmune...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3936677/ https://ncbi.nlm.nih.gov/pubmed/24592352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/9780470942390.mo120154 |
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