A live-attenuated pneumococcal vaccine elicits CD4(+) T-cell dependent class switching and provides serotype independent protection against acute otitis media

Acute otitis media (AOM) caused by Streptococcus pneumoniae remains one of the most common infectious diseases worldwide despite widespread vaccination. A major limitation of the currently licensed pneumococcal vaccines is the lack of efficacy against mucosal disease manifestations such as AOM, acut...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Rosch, Jason W, Iverson, Amy R, Humann, Jessica, Mann, Beth, Gao, Geli, Vogel, Peter, Mina, Michael, Murrah, Kyle A, Perez, Antonia C, Edward Swords, W, Tuomanen, Elaine I, McCullers, Jonathan A
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Blackwell 2014
Θέματα:
Research Articles
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936495/
https://ncbi.nlm.nih.gov/pubmed/24408968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202150
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