A live-attenuated pneumococcal vaccine elicits CD4(+) T-cell dependent class switching and provides serotype independent protection against acute otitis media

Acute otitis media (AOM) caused by Streptococcus pneumoniae remains one of the most common infectious diseases worldwide despite widespread vaccination. A major limitation of the currently licensed pneumococcal vaccines is the lack of efficacy against mucosal disease manifestations such as AOM, acut...

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Detalhes bibliográficos
Main Authors: Rosch, Jason W, Iverson, Amy R, Humann, Jessica, Mann, Beth, Gao, Geli, Vogel, Peter, Mina, Michael, Murrah, Kyle A, Perez, Antonia C, Edward Swords, W, Tuomanen, Elaine I, McCullers, Jonathan A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936495/
https://ncbi.nlm.nih.gov/pubmed/24408968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202150
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