The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor

Tau-tubulin kinase 1 (TTBK1) is a dual-specificity (serine/threonine and tyrosine) kinase belonging to the casein kinase 1 superfamily. TTBK1 is a neuron-specific kinase that regulates tau phosphorylation. Hyperphosphorylation of tau is implicated in the pathogenesis of Alzheimer’s disease. Two kina...

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Detalhes bibliográficos
Main Authors: Kiefer, Susan E., Chang, ChiehYing J., Kimura, S. Roy, Gao, Mian, Xie, Dianlin, Zhang, Yaqun, Zhang, Guifen, Gill, Martin B., Mastalerz, Harold, Thompson, Lorin A., Cacace, Angela M., Sheriff, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2014
Assuntos:
Structural Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936456/
https://ncbi.nlm.nih.gov/pubmed/24637750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14000144
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