Tunicamycin inhibits ganglioside biosynthesis in neuronal cells

The antibiotic tunicamycin blocks the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol phosphate, thereby blocking the synthesis of N-linked oligosaccharide chains on glycoproteins. Its effect on the biosynthesis of gangliosides has not been reported. We report that tunicamycin caused a 70-80% red...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Guarnaccia, Steven P., Shaper, Joel H., Schnaar, Ronald L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1983
Assuntos:	Biological Sciences: Biochemistry
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393639/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6572917/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.6.1551
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