Tunicamycin inhibits ganglioside biosynthesis in neuronal cells
The antibiotic tunicamycin blocks the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol phosphate, thereby blocking the synthesis of N-linked oligosaccharide chains on glycoproteins. Its effect on the biosynthesis of gangliosides has not been reported. We report that tunicamycin caused a 70-80% red...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
1983
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393639/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6572917/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.6.1551 |
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