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Tunicamycin inhibits ganglioside biosynthesis in neuronal cells

The antibiotic tunicamycin blocks the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol phosphate, thereby blocking the synthesis of N-linked oligosaccharide chains on glycoproteins. Its effect on the biosynthesis of gangliosides has not been reported. We report that tunicamycin caused a 70-80% red...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Guarnaccia, Steven P., Shaper, Joel H., Schnaar, Ronald L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1983
Fag:
Biological Sciences: Biochemistry
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393639/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6572917/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.6.1551
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