Evolution- and Structure-Based Computational Strategy Reveals the Impact of Deleterious Missense Mutations on MODY 2 (Maturity-Onset Diabetes of the Young, Type 2)

Heterozygous mutations in the central glycolytic enzyme glucokinase (GCK) can result in an autosomal dominant inherited disease, namely maturity-onset diabetes of the young, type 2 (MODY 2). MODY 2 is characterised by early onset: it usually appears before 25 years of age and presents as a mild form...

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Detalhes bibliográficos
Main Authors: George, Doss C. Priya, Chakraborty, Chiranjib, Haneef, SA Syed, NagaSundaram, Nagarajan, Chen, Luonan, Zhu, Hailong
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936290/
https://ncbi.nlm.nih.gov/pubmed/24578721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.7473
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