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Heterogeneity of Li-Fraumeni Syndrome links to unequal gain-of-function effects of p53 mutations
Mutations of p53 cause not only loss of wild-type function but also gain of novel oncogenic functions (GOF). Accumulating evidence suggest that p53 hotspot mutations may confer different types and magnitudes of GOF. Here we add support to the heterogeneity of mutant p53 GOF by showing their unequal...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3936234/ https://ncbi.nlm.nih.gov/pubmed/24573247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04223 |
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