Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.

Germ-line mutations of the tumor-suppressor gene p53 have been observed in some families with the Li-Fraumeni syndrome (LFS), a familial cancer syndrome in which affected relatives develop a diverse set of early-onset malignancies including breast carcinoma, sarcomas, and brain tumors. The analysis...

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Detalhes bibliográficos
Main Authors: Frebourg, T, Barbier, N, Yan, Y X, Garber, J E, Dreyfus, M, Fraumeni, J, Li, F P, Friend, S H
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1801151/
https://ncbi.nlm.nih.gov/pubmed/7887414
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