Endothelin-1 Promotes Cardiomyocyte Terminal Differentiation in the Developing Heart via Heightened DNA Methylation

Aims: Hypoxia is a major stress on fetal development and leads to induction of endothelin-1 (ET-1) expression. We tested the hypothesis that ET-1 stimulates the terminal differentiation of cardiomyocytes from mononucleate to binucleate in the developing heart. Methods and results: Hypoxia (10.5% O(2...

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Bibliographic Details
Main Authors: Paradis, Alexandra, Xiao, Daliao, Zhou, Jianjun, Zhang, Lubo
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2014
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936032/
https://ncbi.nlm.nih.gov/pubmed/24578615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijms.7802
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