Growth stimulation of A431 cells by epidermal growth factor: identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody.

Epidermal growth factor (EGF) at 3 nM maximally inhibits the proliferation of A431 epidermoid carcinoma cells. We show that at lower concentrations, in the range of 3-100 pM, EGF has a mitogenic effect on A431 cells. In the presence of 100 nM anti-EGF-receptor monoclonal IgG (designated 528), which...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Kawamoto, T, Sato, J D, Le, A, Polikoff, J, Sato, G H, Mendelsohn, J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1983
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC393592/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6298788/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.5.1337
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