ER stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway

The accumulation of improperly folded proteins within the endoplasmic reticulum (ER) generates perturbations known as ER stress that engage the unfolded protein response (UPR). ER stress is involved in many inflammatory pathologies that are also associated with the production of the proinflammatory...

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Main Authors: Shenderov, Kevin, Riteau, Nicolas, Yip, Ronald, Mayer-Barber, Katrin D, Oland, Sandy, Hieny, Sara, Fitzgerald, Pat, Oberst, Andrew, Dillon, Christopher P., Green, Douglas R., Cerundolo, Vincenzo, Sher, Alan
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935725/
https://ncbi.nlm.nih.gov/pubmed/24489101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302549
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