Inhibition of GM3 Synthase Attenuates Neuropathology of Niemann-Pick Disease Type C by Affecting Sphingolipid Metabolism

In several lysosomal storage disorders, including Niemann-Pick disease Type C (NP-C), sphingolipids, including glycosphingolipids, particularly gangliosides, are the predominant storage materials in the brain, raising the possibility that accumulation of these lipids may be involved in the NP-C neur...

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Hauptverfasser: Lee, Hyun, Lee, Jong Kil, Bae, Yong Chul, Yang, Song Hyun, Okino, Nozomu, Schuchman, Edward H., Yamashita, Tadashi, Bae, Jae-sung, Jin, Hee Kyung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korea Society for Molecular and Cellular Biology 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935629/
https://ncbi.nlm.nih.gov/pubmed/24599001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2014.2347
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